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Optimized Response-Adaptive Clinical Trials
Thomas Ondra
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Description for Optimized Response-Adaptive Clinical Trials
Paperback. Series: Bestmasters. Num Pages: 120 pages, 14 black & white illustrations, 2 black & white tables, biography. BIC Classification: PBK; PBT. Category: (P) Professional & Vocational. Dimension: 214 x 149 x 11. Weight in Grams: 168.
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Product Details
Format
Paperback
Publication date
2015
Publisher
Springer Fachmedien Wiesbaden Germany
Number of pages
120
Condition
New
Series
Bestmasters
Number of Pages
102
Place of Publication
Weisbaden, Germany
ISBN
9783658083434
SKU
V9783658083434
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Thomas Ondra
Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
Reviews for Optimized Response-Adaptive Clinical Trials
“It is a remarkably concise exposition of the use of MDPs in a pharmaceutical setting; as such, the book’s audience is the intersection of researchers and students with a sophisticated mathematical background and professionals in the pharmaceutical industry. … the book is a very sophisticated treatise on MDP models for managing response-adaptive clinical trials and both mathematicians and pharmaceutical professionals ... Read more