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Phosphodiesterases as Drug Targets
. Ed(S): Francis, Sharron H.; Conti, Marco; Houslay, Miles D.
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Description for Phosphodiesterases as Drug Targets
paperback. Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Along with its coverage of fresh and emerging ideas in this key field, the book examines all the major concepts related to the design and use of PDE inhibitors. Editor(s): Francis, Sharron H.; Conti, Marco; Houslay, Miles D. Series: Handbook of Experimental Pharmacology. Num Pages: 540 pages, biography. BIC Classification: MMG; PSB; PSF. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 28. Weight in Grams: 819.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Product Details
Format
Paperback
Publication date
2013
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
540
Condition
New
Series
Handbook of Experimental Pharmacology
Number of Pages
522
Place of Publication
Berlin, Germany
ISBN
9783642269455
SKU
V9783642269455
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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