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Martin Beckerman - Cellular Signaling in Health and Disease - 9781441931092 - V9781441931092
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Cellular Signaling in Health and Disease

€ 186.39
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Description for Cellular Signaling in Health and Disease Paperback. This book summarizes the functioning of complex signaling pathways in different tissues and organs of the body in both health and disease. Containing over 150 figures, it presents the latest research findings as a guide to drug design and tissue engineering. Series: Biological and Medical Physics, Biomedical Engineering. Num Pages: 488 pages, 193 black & white illustrations, biography. BIC Classification: MBGR; MQW; PHVN; PSB; PSF. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 25. Weight in Grams: 681.

In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back ... Read more

The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional detailsintegrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

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Product Details

Format
Paperback
Publication date
2010
Publisher
Springer-Verlag New York Inc. United States
Number of pages
488
Condition
New
Series
Biological and Medical Physics, Biomedical Engineering
Number of Pages
470
Place of Publication
New York, NY, United States
ISBN
9781441931092
SKU
V9781441931092
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15

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