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Retroviral Insertion and Oncogene Activation
. Ed(S): Kung, Hsing-Jien; Vogt, Peter K.
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Description for Retroviral Insertion and Oncogene Activation
paperback. Editor(s): Kung, Hsing-Jien; Vogt, Peter K. Series: Current Topics in Microbiology and Immunology. Num Pages: 188 pages, 12 black & white tables, biography. BIC Classification: MJCL; MMFM; PSF. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 10. Weight in Grams: 305.
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration ... Read more
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration ... Read more
Product Details
Format
Paperback
Publication date
2011
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
188
Condition
New
Series
Current Topics in Microbiology and Immunology
Number of Pages
179
Place of Publication
Berlin, Germany
ISBN
9783642765261
SKU
V9783642765261
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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