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Ubiquitin Chains: Degradation and Beyond
Arnab de
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Description for Ubiquitin Chains: Degradation and Beyond
Hardback. Series: Springer Theses. Num Pages: 103 pages, 12 black & white illustrations, 33 colour illustrations, 2 black & white tables, biograph. BIC Classification: MJCM; PSBC; PSF. Category: (G) General (US: Trade). Dimension: 235 x 155 x 8. Weight in Grams: 350.
This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a ... Read more
This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a ... Read more
Product Details
Publisher
Springer International Publishing AG
Format
Hardback
Publication date
2015
Series
Springer Theses
Condition
New
Weight
331g
Number of Pages
103
Place of Publication
Cham, Switzerland
ISBN
9783319149646
SKU
V9783319149646
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Arnab de
Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted ... Read more
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